Ketamine, a Schedule III substance, is a general anesthetic developed in the 1960s, widely used for pain relief and sedation during surgeries, and is being explored for its antidepressant and anti-suicidal properties in treating severe mood disorders and treatment-resistant depression. Recreational use of ketamine, often in liquid or powder form, can lead to hallucinogenic and dissociative effects, with risks of psychological dependency, overdose, and the dangerous "k-hole" experience. Overdose symptoms include severe confusion, unconsciousness, irregular heartbeat, and respiratory failure, requiring immediate medical attention. Harm reduction strategies include using ketamine under medical supervision, recognizing overdose signs, using it with trusted individuals, proper storage, and safe consumption practices.
