TDH Reinforces Importance of Naloxone with Rise in Cychlorphine Fatalities

The Tennessee Department of Health reported more than 30 fatal overdoses associated with cychlorphine in the state since October 2025. Cychlorphine is described as a synthetic opioid approximately ten times more potent than fentanyl, with effects that can include slowed or stopped breathing and loss of responsiveness. Naloxone can reverse a cychlorphine overdose, although repeated doses may be necessary. The notice advises calling 911, administering naloxone, providing rescue breathing, monitoring the person, and using Tennessee treatment and overdose-response resources when assistance is needed.