VA Clinician’s Guide to Medications for PTSD

This professional resource from the VA’s National Center for PTSD reviews medication options using recommendations from the 2023 VA/DoD clinical practice guideline. It explains the role of medication while identifying trauma-focused psychotherapy as the preferred initial treatment. Information compares medications according to the strength of supporting research and distinguishes FDA-approved treatments from off-label uses. It also addresses treatment of nightmares, medication risks, and considerations when other mental health conditions are present. Prescribers and other behavioral health professionals can use the information to support treatment discussions and individualized care.